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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/33474/20
    Bioanalytical Method Using Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry (UHPL-CHRMS) for the Detection of Metformin in Human Plasma
    Research 2021 : January - March
    Ye-Ji Kang, Hyeon-Cheol Jeong, Tae-Eun Kim, Kwang-Hee Shin

    Metformin is the first-line medicine for the treatment of type 2 diabetes. Drug interactions\nbetween metformin and other drugs, food, or beverages cannot only cause changes in the\npharmacokinetic profiles but also affect the efficacy of metformin. The purpose of this study was to\ndevelop a rapid and reliable bioanalytical method for the detection of plasma metformin concentration\nin humans. To remove interfering substances in plasma, acidified acetonitrile (acetonitrile containing\n0.1% formic acid) was added to samples. Ultra-high-performance liquid chromatography (UHPLC)\ncoupled with high resolution mass spectrometry (HRMS) was used to analyze metformin and its\ninternal standard (metformin-d6). Analyte separation was performed on a BEH HILIC analytical\ncolumn..............................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Kang, Ye-Ji, et al. \"Bioanalytical Method Using Ultra-High-Performance Liquid\nChromatography Coupled with High-Resolution Mass Spectrometry (UHPL-CHRMS) for the Detection of Metformin in\nHuman Plasma.\" Molecules 25.20 (2020): 4625.\nhttps://doi:10.3390/molecules25204625\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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